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. 2015 Dec:20:552-71.

Research of DNA repair genes polymorphism XRCC1 and XPD and the risks of thyroid cancer development in persons exposed to ionizing radiation after the Chornobyl disaster

[Article in English, Ukrainian]
V M Shkarupa  1 , S O Henyk-Berezovska  2 , V O Palamarchuk  3 , V V Talko  1 , S V Klymenko  1
Affiliations
  • PMID: 26695931

Research of DNA repair genes polymorphism XRCC1 and XPD and the risks of thyroid cancer development in persons exposed to ionizing radiation after the Chornobyl disaster

[Article in English, Ukrainian]
V M Shkarupa et al. Probl Radiac Med Radiobiol. 2015 Dec.

Abstract
in English, Ukrainian

Objective: The objective of this work was to determine and compare the features of DNA repair gene XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in patients with thyroid cancer (TC), who were exposed to ionizing radiation (IR) as a result of the Chornobyl disaster, and in patients without exposure to ionizing radiation in history.

Materials and methods: Determination of gene XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms was performed by polymerase chain reaction (PCR) in 102 patients with thyroid cancer: 38 people, who were exposed to ionizing radiation due to Chornobyl disaster (members of the accident, and evacuees and residents from controlled areas contaminated with radionuclides), 64 individuals without exposure to ionizing radiation in history and 41 persons residents of Ukraine without cancer pathology in the control group. For comparison of the data on spontaneous and radiation-associated thyroid cancer and settlement of allele frequencies differences and risk of cancer pathology were used the literature data on control groups of populations of Russia, Belarus and Poland.

Results: Comparing to the literature data on XRCC1 Arg399Gln polymorphisms in radiation-exposed individuals without cancer pathology, the risk of thyroid cancer in homozygous minor allele XRCC1 Gln399Gln carriers, who were exposed to ionizing radiation was significantly increased: OR = 4,14, p = 0,001 (CI95 % 1,72-9,93). In homozygous carriers of the minor allele of the gene XPD Lys751Gln, exposed to IR, revealed increased risk of thyroid cancer: OR = 3,30, p = 0,05 (CI 95 % 0,82-14,14), when compared with the control group of Ukrainian population.

Conclusions: The carriage of homozygous minor allele Gln399Gln XRCC1 and XPD Gln751Gln of DNA repair genes is a risk factor for thyroid cancer under the influence of ionizing radiation in research group of Ukrainian population.

Metoiu roboty bulo vyznachyty ta porivniaty osoblyvosti polimorfizmu geniv reparatsii XRCC1 Arg399Gln ta XPD Lys751Gln u khvorykh na rak shchytopodibnoi zalozy (RShchZ), iaki zaznaly dii ionizuiuchoi radiatsii vnaslidok avarii na Chornobyl's'kii AES, ta u khvorykh bez vplyvu ionizuiuchogo vyprominennia (IV) v anamnezi. Materialy i metody. Vyznachennia polimorfizmu geniv XRCC1 Arg399Gln ta XPD Lys751Gln provodylos' shliakhom polimeraznoi lantsiugovoi reaktsii (PLR) u 102 khvorykh na RShchZ: 38 osib, iaki zaznaly dii ionizuiuchoi radiatsii vnaslidok avarii na Chornobyl'skii AES (uchasnyky likvidatsii naslidkiv avarii, evakuiovani ta meshkantsi kontrol'ovanykh terytorii, zabrudnenykh radionuklidamy), 64 osoby bez vplyvu ionizuiuchogo vyprominennia v anamnezi ta 41 osoba kontrol'noi grupy zhyteliv Ukrainy bez onkopatologii. Dlia porivniannia otrymanykh danykh shchodo spontannogo ta radiatsiino-asotsiiovanogo RShchZ ta rozrakhunku vidminnostei chastot alelei i ryzyku vynyknennia onkopatologii vykorystovuvaly dani literatury shchodo kontrol'nykh grup populiatsii Rosiis'koi Federatsii, Bilorusii, Pol'shchi. Rezul'taty. Pry porivnianni z danymy literatury shchodo polimorfizmu XRCC1 u radiatsiino-eksponovanykh osib bez onkopatologii, ryzyk rozvytku RShchZ u gomozygotnykh nosiiv minornogo aleliu XRCC1 Gln399Gln u osib, iaki zaznaly vplyvu IV, vyiavyvsia dostovirno pidvyshchenym: OR = 4,14, p = 0,001 (CI 95 % 1,72–9,93). U gomozygotnykh nosiiv minornykh alelei gena XPD Lys751Gln, iaki zaznaly vplyvu IV, vyiavleno zbil'shennia ryzyku rozvytku RShchZ: OR = 3,30, p = 0,05 (CI 95 % 0,82–14,14) porivniano z kontrol'noiu grupoiu ukrains'koi populiatsii. Vysnovky. Nosiistvo gomozygotnykh minornykh alelei geniv reparatsii DNK XRCC1 Gln399Gln ta XPD Gln751Gln ie faktorom ryzyku rozvytku RShchZ za umov vplyvu ionizuiuchogo vyprominiuvannia v doslidzhenii grupi ukrains'koi populiatsii.

Keywords: Chornobyl disaster; XRCC1 and XPD gene polymorphisms; thyroid cancer.

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