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. 1989 Jun;33(6):951-6.
doi: 10.1128/AAC.33.6.951.

SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams

L Gutmann  1 , B Ferré, F W Goldstein, N Rizk, E Pinto-Schuster, J F Acar, E Collatz
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SHV-5, a novel SHV-type beta-lactamase that hydrolyzes broad-spectrum cephalosporins and monobactams

L Gutmann et al. Antimicrob Agents Chemother. 1989 Jun.

Abstract

SHV-5 (pI 8.2), a novel broad-spectrum beta-lactamase encoded by a ca. 150-kilobase plasmid, was found in Klebsiella pneumoniae 160. SHV-5 beta-lactamase caused decreased susceptibility to most penicillins, cephalosporins, and monobactams, except imipenem and compounds which have a C6 or C7 alpha-methoxy substituent. beta-Lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) inhibited its activity and showed a synergistic effect when associated with different hydrolyzable beta-lactam compounds. Hybridization studies suggested that this enzyme may be related to, or derived from, the SHV enzyme. Increased MICs of cephamycins and temocillin associated with a decreased synergistic effect of the inhibitors on K. pneumoniae 160 might be linked to a decrease in two outer membrane proteins.

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References

    1. J Antibiot (Tokyo). 1972 Oct;25(10):622-4 - PubMed
    1. Infection. 1987 Jul-Aug;15(4):257-9 - PubMed
    1. J Antimicrob Chemother. 1987 Sep;20(3):323-34 - PubMed
    1. Antimicrob Agents Chemother. 1988 Jan;32(1):9-14 - PubMed
    1. Biochem J. 1988 Mar 1;250(2):313-24 - PubMed

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