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Review
. 2015 Dec;29(6):849-57.
doi: 10.1016/j.beem.2015.10.001. Epub 2015 Oct 9.

Reprogramming of human exocrine pancreas cells to beta cells

Willem Staels  1 , Yves Heremans  2 , Harry Heimberg  3
Affiliations
Review

Reprogramming of human exocrine pancreas cells to beta cells

Willem Staels et al. Best Pract Res Clin Endocrinol Metab. 2015 Dec.

Abstract

One of the key promises of regenerative medicine is providing a cure for diabetes. Cell-based therapies are proving their safety and efficiency, but donor beta cell shortages and immunological issues remain major hurdles. Reprogramming of human pancreatic exocrine cells towards beta cells would offer a major advantage by providing an abundant and autologous source of beta cells. Over the past decade our understanding of transdifferentiation processes greatly increased allowing us to design reprogramming protocols that fairly aim for clinical trials.

Keywords: beta cell; diabetes; pancreas; reprogramming; transdifferentiation.

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