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Review
. 2015 Nov;3(19):287.
doi: 10.3978/j.issn.2305-5839.2015.10.45.

Determinants of the incidence of Duchenne muscular dystrophy

Alan Edmund Stark  1
Affiliations
Review

Determinants of the incidence of Duchenne muscular dystrophy

Alan Edmund Stark. Ann Transl Med. 2015 Nov.

Abstract

Duchenne muscular dystrophy (DMD), an X-linked disorder, is the most common muscular dystrophy with an incidence in boys of about 200 per million births. It presents in early childhood leading to death in early teens. Its relatively high incidence and severity have stimulated many studies from epidemiological to curative. Recent advances in molecular biology have opened up the possibility of carrier identification and potential reduction of the incidence of cases. This paper gives a population genetics model which can be used to predict the reduction in incidence.

Keywords: Duchenne muscular dystrophy (DMD); incidence; mutation.

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

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