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. 2015 Dec 23:4:e12760.
doi: 10.7554/eLife.12760.

Signaling the differences between cilia

Polina Lishko  1 , Yuriy Kirichok  2
Affiliations

Signaling the differences between cilia

Polina Lishko et al. Elife. .

Abstract

Calcium ion channels that determine many of the properties of cilia are different in motile cilia as compared to primary cilia and flagella.

Keywords: biophysics; calcium; cell biology; ion channels; motile cilia; mouse; patch clamp; structural biology.

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Conflict of interest statement

The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. The diversity of cilia.
There are two types of cilia, primary cilia and undulipodia, which are distinguished by differences in the structure of their axoneme. The level of calcium ions (Ca2+) inside the cilia is regulated by specialized ion channels. (A) The main Ca2+ channel for primary cilia has been identified as the PKD1L1/PKD2L1 complex. (B) There are two types of undulipodia: motile cilia and flagella. The main Ca2+ channel of mammalian flagella was identified as a protein called CatSper in 2013. Doerner et al. have now identified an L-type voltage-gated Ca2+ channel (Cav1 family) as the main Ca2+ channel for motile cilia.
See this image and copyright information in PMC

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  • doi: 10.7554/eLife.11066

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