Editorial
doi: 10.1080/15384101.2015.1105694.
TORn about SASP regulation
Affiliations
- PMID: 26697828
- PMCID: PMC4825754
- DOI: 10.1080/15384101.2015.1105694
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Editorial
TORn about SASP regulation
Cell Cycle.
2015.
No abstract available
Keywords: MAPKAPK2; SASP; Senescence; ZFP36L1; aging; cancer; mTOR; oncogene-induced senescence; senescence-associated secretory phenotype.
Figures
mTOR regulates the SASP. In senescent cells, mTOR regulates the SASP by controlling the translation of IL1A and MAPKAPK2. MAPKAPK2 phosphorylates and inhibits the RNA-binding protein ZFP36L1, thereby preventing the degradation of SASP transcripts by ARE-mediated decay. Additionally, IL1α activates NF-κB in a cell-autonomous manner to promote the transcription of SASP genes. Upon mTOR inhibition, ZFP36L1 degrades SASP transcripts and the IL1α feedback loop is abrogated.
Comment on
- doi: 10.1038/ncb3225
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