Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jan;8(1):77-84.
doi: 10.2217/epi.15.96. Epub 2015 Dec 23.

Epigenetic dysregulation in follicular lymphoma

Shamzah Araf  1 , Jessica Okosun  1 , Lola Koniali  1 , Jude Fitzgibbon  1 , James Heward  1
Affiliations
Review

Epigenetic dysregulation in follicular lymphoma

Shamzah Araf et al. Epigenomics. 2016 Jan.

Abstract

The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.

Keywords: CREBBP; EP300; EZH2; KMT2D; epigenetics; follicular lymphoma; histone acetylation; histone methylation; noncoding RNA.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure J Fitzgibbon is supported by a Cancer Research UK Programme Grant (15968). S Araf is a recipient of a Cancer Research UK Clinical Research Fellowship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. A model for how mutations of epigenetic regulators can lead to dysregulation of H3K4 and H3K27 modification in follicular lymphoma.
Loss of function (-) and gain of function (+) mutations confer a repressed chromatin state and alongside promoter hypermethylation (CpG-me) may act to repress gene expression.
See this image and copyright information in PMC

References

    1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues (4th Edition) IARC Press; Lyon, France: 2008.
    1. Kridel R, Sehn LH, Gascoyne RD. Pathogenesis of follicular lymphoma. J. Clin. Invest. 2012;122(10):3424–3431. - PMC - PubMed
    1. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science. 1985;229(4720):1390–1393. - PubMed
    1. Weiss LM, Warnke RA, Sklar J, Cleary ML. Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. N. Engl. J. Med. 1987;317(19):1185–1189. - PubMed
    1. Roulland S, Lebailly P, Lecluse Y, Heutte N, Nadel B, Gauduchon P. Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals. Leukemia. 2006;20(1):158–162. - PubMed

Publication types

LinkOut - more resources