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Comment
. 2016 Jan 12;23(1):1-2.
doi: 10.1016/j.cmet.2015.11.001. Epub 2015 Nov 19.

Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

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Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

Sergey Kasparov. Cell Metab. .
Free article

Abstract

The role of lactate in the brain has been controversial. In this issue, Mächler et al. (2015) present data from in vivo experiments suggesting that there is a downward gradient of lactate in the brain. They provide a mechanistic basis for the proposed export of lactate from astrocytes to neurons.

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  • In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.
    Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B. Mächler P, et al. Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19. Cell Metab. 2016. PMID: 26698914

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