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Comment
. 2015 Dec 29;112(52):15777-8.
doi: 10.1073/pnas.1520869112. Epub 2015 Dec 23.

Energetics and population genetics at the root of eukaryotic cellular and genomic complexity

Eugene V Koonin  1
Affiliations
Comment

Energetics and population genetics at the root of eukaryotic cellular and genomic complexity

Eugene V Koonin. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Cellular organization-driven evolutionary scenario of eukaryogenesis. Eukaryogenesis is represented by three stages: 1, α-proteobacterium engulfed by a Loki-like archaeon becomes the proto-mitochondrial endosymbiont; excess energy production; 2, excess energy production leads to cell enlargement accompanied by intracellular compartmentalization (emergence of endomembranes) and a drop in Ne; 3, expansion and remodeling of the genome including insertion of endosymbiont DNA (both genes and introns) accompanied by shrinking of the endosymbiont genome and linearization of the chromosomes; further evolution of intracellular organization including the origin of the nucleus from the endomembranes, conceivably, as a protective device against translation of aberrant, intron-containing transcripts (14). The cellular complexity of the Loki-like putative host of the endosymbiont is unknown; the figure only includes some inferences from the gene repertoire of the Lokiarchaeon. Abbreviations: CC, circular chromosome; CS, cytoskeleton; EM, endomembranes; LC, linear chromosomes; N, nucleus.
See this image and copyright information in PMC

Comment on

  • The bioenergetic costs of a gene.
    Lynch M, Marinov GK. Lynch M, et al. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15690-5. doi: 10.1073/pnas.1514974112. Epub 2015 Nov 2. Proc Natl Acad Sci U S A. 2015. PMID: 26575626 Free PMC article.

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