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. 2016 Mar;26(3):483-7.
doi: 10.4014/jmb.1512.12018.

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia

Il-Dong Choi  1 , Sung-Hwan Kim  1 , Ji-Woong Jeong  1 , Dong Eun Lee  1 , Chul-Sung Huh  2 , Seong Soo Hong  3 , Jae-Hun Sim  1 , Young-Tae Ahn  1
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Free article

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia

Il-Dong Choi et al. J Microbiol Biotechnol. 2016 Mar.
Free article

Abstract

The triglyceride-lowering effect of probiotics Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 were investigated. Male SD Wistar rats were randomly divided into three groups and fed high-fat diet (HFD), HFD and probiotics (5 X 10(9) CFU/day of L. plantarum KY1032 and 5 X 10(9) CFU/day of L. curvatus HY7601), or normal diet for 6 weeks. Probiotic treatment significantly lowered the elevated plasma triglyceride and increased plasma free fatty acid, glycerol, and plasma apolipoprotein A-V (ApoA-V) levels. The probiotic-treated group showed elevated hepatic mRNA expression of PPARα, bile acid receptor (FXR), and ApoA-V. These results demonstrate that L. plantarum KY1032 and L. curvatus HY7601 lower triglycerides in hypertriglyceridemic rats by upregulating ApoA-V, PPARα, and FXR.

Keywords: Lactobacillus curvatus; Lactobacillus plantarum; Triglyceride; apolipoprotein A-V; probiotics.

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