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. 2016 Jan 19;32(2):632-6.
doi: 10.1021/acs.langmuir.5b04399. Epub 2016 Jan 5.

Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles

Dongsheng Wang  1 , Si Wu  1
Affiliations

Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles

Dongsheng Wang et al. Langmuir. .

Abstract

Red-light-responsive supramolecular valves constructed by tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) were used to control drug release from mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular valves with mAzo by host-guest interaction and closed the nanopores. Red light was able to open the supramolecular valves and induce DOX release even in deep tissue.

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