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Review
. 2016 Jan;18(1):2.
doi: 10.1007/s11926-015-0554-8.

Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

Giuseppina Stifano  1 , Romy Beatriz Christmann  2
Affiliations
Review

Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

Giuseppina Stifano et al. Curr Rheumatol Rep. 2016 Jan.

Abstract

The pathogenesis of systemic sclerosis is still unknown, although immune cells, mainly macrophages/monocytes, may have an important role in initiating and/or perpetuating the disease. Macrophages and monocytes are often classified as pro-inflammatory M1 phenotype or classic activation and pro-fibrotic/anti-inflammatory M2 phenotype or alternative activation. In this review, we highlighted the most relevant research regarding the involvement of macrophages/monocytes in the pathogenesis of this complex disease.

Keywords: Fibrosis; Macrophages; Monocytes; Pathogenesis; Scleroderma; Systemic sclerosis.

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References

    1. Arthritis Res Ther. 2013;15(3):R69 - PubMed
    1. Arthritis Rheum. 2003 Jul;48(7):1979-91 - PubMed
    1. Rheumatol Int. 1999;19(1-2):39-46 - PubMed
    1. F1000Prime Rep. 2014 Mar 03;6:13 - PubMed
    1. J Immunol. 1997 Aug 1;159(3):1140-9 - PubMed

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