Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan 13;138(1):48-51.
doi: 10.1021/jacs.5b10937. Epub 2015 Dec 24.

Binding Hydrated Anions with Hydrophobic Pockets

Punidha Sokkalingam  1 , Joshua Shraberg  2 , Steven W Rick  2 , Bruce C Gibb  1
Affiliations

Binding Hydrated Anions with Hydrophobic Pockets

Punidha Sokkalingam et al. J Am Chem Soc. .

Abstract

Using a combination of isothermal titration calorimetry and quantum and molecular dynamics calculations, we demonstrate that relatively soft anions have an affinity for hydrophobic concavity. The results are consistent with the anions remaining partially hydrated upon binding, and suggest a novel strategy for anion recognition.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative calculated structures of the complexes between 1 and perchlorate (left) and iodide (right).
See this image and copyright information in PMC

References

    1. Sessler JL, Gale PA, Cho WS. Anion Receptor Chemistry. Royal Society of Chemistry; Cambridge: 2006.
    1. Gale PA, Busschaert N, Haynes CJ, Karagiannidis LE, Kirby IL. Chem Soc Rev. 2013;43:205–241. - PubMed
    2. Gale PA, Steed JW. Supramolecular Chemistry: From Molecules to Nanomaterials. John Wiley and Sons; 2012.
    3. Caballero A, Zapata F, Beer PD. Coordination Chemistry Reviews. 2013;257(17-18):2434–2455.
    4. Hirsch AKH, Fischer FR, Diederich F. Angew Chem Int Ed. 2007;46:338–352. - PubMed
    5. Berryman O, Johnson DW. Chem Commun. 2009:3143–3153. - PubMed
    1. Kubik S. Chem Soc Rev. 2010;39(10):3648–63. - PubMed
    1. García-España E, Díaz P, Llinares JM, Bianchi A. Coordination Chemistry Reviews. 2006;250(23-24):2952–2986.
    2. Schmidtchen FP. Coordination Chemistry Reviews. 2006;250(23-24):2918–2928.
    3. O'Neil EJ, Smith BD. Coordination Chemistry Reviews. 2006;250(23-24):3068–3080.
    4. Schiessl P, Schmidtchen FP. The Journal of Organic Chemistry. 1994;59(3):509–511.
    5. Schmuck C, Schwegmann M. J Am Chem Soc. 2005;127(10):3373–9. - PubMed
    6. Metzger A, Lynch VM, Anslyn EV. Angewandte Chemie International Edition in English. 1997;36(8):862–865.
    7. Schmuck C, Wich P. The development of artificial receptors for small pepticles using combinatorial approaches. In: Schrader T, editor. Creative Chemical Sensor Systems. Vol. 277. Springer-Verlag Berlin; Berlin: 2007. pp. 3–30.
    1. Lim JY, Beer PD. Chem Commun (Camb) 2015;51(17):3686–8. - PubMed
    2. Langton MJ, Robinson SW, Marques I, Felix V, Beer PD. Nature Chemistry. 2014;6(12):1039–1043. - PubMed

Publication types

MeSH terms

LinkOut - more resources