Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium

Affiliations

¹ Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Division of Emergency Medicine; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address: morrisonl@smh.ca.
² Clinical Trials Centre, University of Washington, WA, USA.
³ Johns Hopkins Medicine, Baltimore, MD, USA.
⁴ Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁵ The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
⁶ Cardiac Prevention Centre & Women's Cardiovascular Health, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁷ University of Iowa Children's Hospital, Carver College of Medicine, Iowa City, IA, USA.
⁸ Division of Cardiovascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁹ Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Insitute, University Health Network, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

PMID: 26705971
PMCID: PMC4761304
DOI: 10.1016/j.resuscitation.2015.12.002

Multicenter Study

Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium

Laurie J Morrison et al. Resuscitation. 2016 Mar.

. 2016 Mar:100:76-81.

doi: 10.1016/j.resuscitation.2015.12.002. Epub 2015 Dec 17.

Affiliations

¹ Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada; Division of Emergency Medicine; Department of Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address: morrisonl@smh.ca.
² Clinical Trials Centre, University of Washington, WA, USA.
³ Johns Hopkins Medicine, Baltimore, MD, USA.
⁴ Rescu, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁵ The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
⁶ Cardiac Prevention Centre & Women's Cardiovascular Health, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁷ University of Iowa Children's Hospital, Carver College of Medicine, Iowa City, IA, USA.
⁸ Division of Cardiovascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁹ Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada; Toronto Health Economics and Technology Assessment Collaborative, Toronto General Research Insitute, University Health Network, and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

PMID: 26705971
PMCID: PMC4761304
DOI: 10.1016/j.resuscitation.2015.12.002

Abstract

Introduction: This study examined the relationship between gender and outcomes of non-traumatic out-of-hospital cardiac arrest (OHCA).

Methods: All eligible, consecutive, non-traumatic Emergency Medical Services (EMS) treated OHCA patients in the Resuscitation Outcomes Consortium between December 2005 and May 2007. Patient age was analyzed as a continuous variable and stratified in two age cohorts: 15-45 and >55 years of age (yoa). Unadjusted and adjusted (based on Utstein characteristics) chi square tests and logistic regression models were employed to examine the relationship between gender, age, and survival outcomes.

Results: This study enrolled 14,690 patients: of which 36.4% were women with a mean age of 68.3 and 63.6% of them men with a mean age of 64.2. Women survived to hospital discharge less often than men (6.4% vs. 9.1%, p<0.001); the unadjusted OR was 0.69, 95%CI: 0.60, 0.77 whereas when adjusted for all Utstein predictors the difference was not significant (OR: 1.16, 95%CI: 0.98, 1.36, p=0.07). The adjusted survival rate for younger women (15-45 yoa) was 11.1% vs. 9.8% for younger men (OR: 1.66, 95%CI: 1.04, 2.64, p=0.03) but no difference in discharge rates was observed in the >55 cohort (OR: 0.94, 95%CI: 0.78, 1.15, p=0.57).

Conclusions: Women who suffer OHCAs have lower rates of survival and have unfavourable Utstein predictors. When survival is adjusted for these predictors survival is similar between men and women except in younger women suggesting that age modifies the association of gender and survival from OHCA; a result that supports a protective hormonal effect among premenopausal women.

Keywords: Adult population; Cardiopulmonary resuscitation; Gender; Heart arrest; Out of hospital cardiac arrest.

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References

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Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium

Affiliations

Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical