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. 2016 Jan;17(1):20-7.
doi: 10.1111/1751-2980.12309.

Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection

Takahiro Uotani  1   2 , Mitsushige Sugimoto  3 , Hitomi Ichikawa  4 , Shingo Tanaka  1   2 , Hiroyuki Nagashima  5 , Tomohisa Uchida  6 , David Y Graham  1 , Yoshio Yamaoka  1   2
Affiliations

Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection

Takahiro Uotani et al. J Dig Dis. 2016 Jan.

Abstract

Objectives: Gastric cancer is etiologically related to interactions between Helicobacter pylori (H. pylori) infection, environmental and host factors. Gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. Prostate stem cell antigen (PSCA) polymorphisms have been associated with an increased risk of gastric cancer. We aimed to examine the interaction between PSCA polymorphisms and H. pylori in the progression of H. pylori-related gastritis.

Methods: The genotypes (TT, TC and CC) of PSCA single nucleotide polymorphism rs2294008 among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori-related gastritis [neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia (IM)] using the updated Sydney system.

Results: Biopsies from 339 participants were included. The proportion of biopsies with IM was significantly (P < 0.05) greater in those with the TT genotype than in either those with the CT or CC genotype. Although no significant differences were found in inflammation or H. pylori density scores, the scores for IM at both gastric corpus and antrum among participants infected by H. pylori with the TT genotype was significantly (P < 0.05) greater than in the C allele carriers.

Conclusion: PSCA TT genotype is associated with a more than a threefold increase in the prevalence and the extent of gastric mucosal IM compared to C allele carriers among H. pylori-infected Bhutanese.

Keywords: Helicobacter pylori; gastric neoplasms; intestinal metaplasia; prostate stem cell antigen gene; single nucleotide polymorphism.

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Conflict of interest statement

Disclosure of funding and conflicts of interest

Conflict of Interest

TU has received research grants from Institute for Fermentation, Osaka (IFO), Japan.

DYG is a consultant for RedHill Biopharma and has received research support. He is also a consultant for Otsuka Pharmaceuticals and for BioGaia.

Figures

Figure 1
Figure 1. Relationship between PCSA genotypes and gastroduodenal disease
Although the relation between gastric cancer, gastroduodenal ulcer and PSCA genotypes have been shown, the relationship between gastric histological changes and PSCA genetic polymorphism in H. pylori infection remains unclear. Superscript on figure means reference number.
Figure 2
Figure 2. Design of study
We recruited 401 Bhutanese volunteers. After excluding samples where background data was unknown or the samples were insufficient for DNA extraction or genotyping, a total of 339 samples remained.
Figure 3
Figure 3. The proportion of intestinal metaplasia with H. pylori infection in each gastric site
The proportion with intestinal metaplasia was significantly greater with the TT genotype than with the CT or CC genotypes in both the corpus and antral mucosa (P <0.05). In all genotypes, the proportion of intestinal metaplasia in the antrum was significantly higher than that in the corpus (P < 0.05).
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