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Review
. 2015 Dec;39(6):468-77.
doi: 10.4093/dmj.2015.39.6.468.

Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?

Sung Hoon Kim  1
Affiliations
Review

Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?

Sung Hoon Kim. Diabetes Metab J. 2015 Dec.

Abstract

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.

Keywords: Diagnosis; Maturity-onset diabetes of the young; Personalized treatment.

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Conflict of interest statement

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Diagnostic algorithm for maturity-onset diabetes of the young (MODY). T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus.
See this image and copyright information in PMC

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