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. 2016 Mar;84(3):266-7.
doi: 10.1016/j.diagmicrobio.2015.11.013. Epub 2015 Nov 17.

Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

Sophie Trouillet-Assant  1 , Florent Valour  2 , William Mouton  3 , Patrícia Martins-Simões  3 , Sébastien Lustig  4 , Frédéric Laurent  3 , Tristan Ferry  2 ; Lyon BJI study group
Collaborators, Affiliations

Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

Sophie Trouillet-Assant et al. Diagn Microbiol Infect Dis. 2016 Mar.

Abstract

Comparison of methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for bone and joint infection (BJI, n=73) and nasal colonization (n=57) revealed similar prevalence of β-lactamase (blaZ) type A production, associated with cefazolin hydrolysis, suggesting that blaZ type A-carrying MSSA isolates implicated in postoperative BJI are not selected by cefazolin prophylaxis.

Keywords: Bone and joint infection; Cefazolin; Prophylaxis; Staphylococcus aureus; β-Lactamase.

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