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Review
. 2016 Feb:38:75-85.
doi: 10.1016/j.coi.2015.11.005. Epub 2015 Dec 17.

Differentiation of human innate lymphoid cells (ILCs)

Kerstin Juelke  1 , Chiara Romagnani  2
Affiliations
Review

Differentiation of human innate lymphoid cells (ILCs)

Kerstin Juelke et al. Curr Opin Immunol. 2016 Feb.

Abstract

During the last years, a high complexity in innate lymphoid lineages now collectively referred to as innate lymphoid cells (ILCs) has been revealed. ILCs can be grouped according to their effector functions and transcriptional requirements into three main groups, termed group 1, 2 and 3 ILCs. The differentiation of ILC lineages from hematopoietic precursors and the molecular switches guiding their developmental fate have started to be characterized both in mice and humans. In this review, we discuss the origin, differentiation stages and plasticity of human ILC subsets as well as the signals that drive ILC lineage commitment and acquisition of their unique effector programs.

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