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Review
. 2016 May-Jun;61(3):314-7.
doi: 10.1016/j.survophthal.2015.12.007. Epub 2015 Dec 19.

Update on ocular cicatricial pemphigoid and emerging treatments

Munther M Queisi  1 , Mike Zein  1 , Neerav Lamba  1 , Halea Meese  1 , Charles Stephen Foster  2
Affiliations
Review

Update on ocular cicatricial pemphigoid and emerging treatments

Munther M Queisi et al. Surv Ophthalmol. 2016 May-Jun.

Abstract

Mucous membrane pemphigoid is a systemic disorder that primarily affects mucous membranes. When localized to the conjunctiva, it is known as ocular cicatricial pemphigoid, a potentially blinding disease. Ocular cicatricial pemphigoid is an indication for systemic immunosuppressive treatment to achieve adequate remission. Immunosuppressive agents are selected with a "stepladder" approach, commencing with medications having the fewest side effects. We provide an update of the literature on immunomodulatory agents since 2011 as additional treatment modalities have been explored in the last 4 years.

Keywords: alkylating agents; biologic agents; chemotherapy; immunomodulatory therapy; mucus membrane pemphigoid; ocular cicatricial pemphigoid.

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