Dopaminergic reward sensitivity can promote adolescent health: A new perspective on the mechanism of ventral striatum activation
- PMID: 26708774
- PMCID: PMC4727991
- DOI: 10.1016/j.dcn.2015.10.010
Dopaminergic reward sensitivity can promote adolescent health: A new perspective on the mechanism of ventral striatum activation
Abstract
The prevailing view in the field of adolescent brain development is that heightened activity in the mesolimbic dopaminergic reward system serves as a liability, orienting adolescents toward risky behaviors, increasing their sensitivity to social evaluation and loss, and resulting in compromised well-being. Several findings inconsistent with this deficit view challenge the perspective that adolescent reward sensitivity largely serves as a liability and highlights the potential adaptive function that heightened striatal reactivity can serve. The goal of this review is to refine our understanding of dopaminergic reward sensitivity in adolescence. I review several studies showing that ventral striatum activation serves an adaptive function for adolescents' health and well being relating to declines in both risk taking and depression and increases in cognitive persistence and achievement.
Keywords: Adolescence; Brain development; Health; Rewards; Risk taking.
Published by Elsevier Ltd.
References
-
- Aklin W.M., Lejuez C.W., Zvolensky M.J., Kahler C.W., Gwadz M. Evaluation of behavioral measures of risk taking propensity with innercity adolescents. Behav. Res. Ther. 2005;43:215–228. - PubMed
-
- Alexander G.E., De Long M.R. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 1986;9:357–381. - PubMed
-
- Andersen S.L., Rutstein M., Benzo J.M., Hostetter J.C., Teicher M.H. Sex differences in dopamine receptor overproduction and elimination. Neuroreport. 1997;8:1495–1498. - PubMed
-
- Badanich K.A., Adler K.J. Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi. Eur. J. Pharmacol. 2006;550:95–106. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
