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Comment
. 2016 Jan;48(1):10-1.
doi: 10.1038/ng.3478.

The requirement of iron transport for lymphocyte function

Bernice Lo  1
Affiliations
Comment

The requirement of iron transport for lymphocyte function

Bernice Lo. Nat Genet. 2016 Jan.

Abstract

Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.

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Comment on

  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
    Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS. Jabara HH, et al. Nat Genet. 2016 Jan;48(1):74-8. doi: 10.1038/ng.3465. Epub 2015 Dec 7. Nat Genet. 2016. PMID: 26642240 Free PMC article.

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