Review
doi: 10.1093/jb/mvv123.
Epub 2015 Dec 28.
Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators
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- PMID: 26711237
- DOI: 10.1093/jb/mvv123
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Review
Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators
J Biochem.
2016 Mar.
Abstract
Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
Keywords: MAML; Mastermind; Notch signalling; signal transduction; transcription.
© The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.
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