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Review
. 2016 Mar;159(3):287-94.
doi: 10.1093/jb/mvv123. Epub 2015 Dec 28.

Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators

Motoo Kitagawa  1
Affiliations
Review

Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators

Motoo Kitagawa. J Biochem. 2016 Mar.

Abstract

Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.

Keywords: MAML; Mastermind; Notch signalling; signal transduction; transcription.

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