Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Apr;13(4):962-3.
doi: 10.1016/j.hrthm.2015.12.025. Epub 2015 Dec 19.

Atrial fibrillation: Can electrograms be interpreted without repolarization information?

Affiliations
Editorial

Atrial fibrillation: Can electrograms be interpreted without repolarization information?

Sanjiv M Narayan et al. Heart Rhythm. 2016 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Repolarization information simplifies interpretation of atrial electrophysiology. Simultaneous monophasic action potentials (top) and bipolar electrograms (bottom) in human left atrium during atrial fibrillation (AF). Top: Beat-to-beat tracking of repolarization time, indicated by time to ≈70% repolarization (APD70) in the monophasic action potential, shows that clinical electrograms in human AF may poorly indicate true local activation. Several deflections (nonfractionated and fractionated) fall well within APD70 and likely are far-field (see text and Narayan et al).

Comment on

References

    1. Chugh A. Complex fractionated atrial electrograms in catheter ablation of atrial fibrillation: dead and buried? Circ Arrhythm Electrophysiol. 2015;8:999–1001. - PubMed
    1. de Groot NM, Houben RP, Smeets JL, Boersma E, Schotten U, Schalij MJ, Crijns H, Allessie MA. Electropathological substrate of longstanding persistent atrial fibrillation in patients with structural heart disease: epicardial breakthrough. Circulation. 2010;122:1674–1682. - PubMed
    1. Bode F, Kilborn M, Karasik P, Franz MR. The repolarization-excitability relationship in the human right atrium is unaffected by cycle length, recording site and prior arrhythmias. J Am Coll Cardiol. 2001;37:920–925. - PubMed
    1. Narayan SM, Franz MR, Clopton P, Pruvot EJ, Krummen DE. Repolarization alternans reveals vulnerability to human atrial fibrillation. Circulation. 2011;123:2922–2930. - PMC - PubMed
    1. Schricker A, Rostamian A, Lalani G, Krummen DE, Narayan SM. Human atrial fibrillation initiates by organized not disorganized mechanisms. Circ Arrhythm Electrophysiol. 2014;7:816–824. - PMC - PubMed