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Comment
. 2015 Dec 27;108(2):djv390.
doi: 10.1093/jnci/djv390. Print 2016 Feb.

Response

Nicolas Wentzensen  1 , Barbara Fetterman  2 , Philip Castle  2 , Mark Schiffman  2 , Shannon Wood  2 , Diane Tokugawa  2 , Clara Bodelon  2 , Nancy Poitras  2 , Tom Lorey  2 , Walter Kinney  2
Affiliations
Comment

Response

Nicolas Wentzensen et al. J Natl Cancer Inst. .
No abstract available

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Figures

Figure 1.
Figure 1.
The figure shows an idealized scenario of a screening and triage strategy to detect cervical precancers. All women are tested for human papillomavirus (HPV) and triage testing is restricted to HPV-positives. Gray women represent HPV-negative women. Blue women are HPV-positive but negative for the triage marker and do not have precancer. Purple women are HPV-positive and test positive for the triage marker. The black woman is positive for HPV and the triage marker and is diagnosed with precancer. On the left side, the absolute risk estimates after testing for DS (positive predictive value and complement of the negative predictive value) are shown for the full population as described by Dr. Garner (1). On the right side, the risk estimates are shown for the group of HPV-positive women as published in our paper (3). Clinical management thresholds are shown in relationship to the absolute risk estimates. In this idealized scenario, women testing negative for HPV but positive for the triage marker are not shown, as they would not be identified in the sequential testing strategy. cNPV = complement of the negative predictive value; PPV = positive predictive value.
See this image and copyright information in PMC

Comment on

References

    1. Huh WK, Ault KA, Chelmow D, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. J Low Genit Tract Dis. 2015;19 (2):91–96. - PubMed
    1. Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC, Castle PE. Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst. 2011;103 (5):368–383. - PMC - PubMed
    1. Gage JC, Schiffman M, Katki HA, et al. Reassurance against future risk of precancer and cancer conferred by a negative human papillomavirus test. J Natl Cancer Inst. 2014;106 (8):dju153. - PMC - PubMed
    1. Wentzensen N, Schiffman M, Palmer T, Arbyn M. Triage of HPV positive women in cervical cancer screening. J Clin Virol. 2015;S1386-6532(15)00749-0. - PMC - PubMed
    1. Wentzensen N, Fetterman B, Castle PE, et al. p16/Ki-67 Dual Stain Cytology for Detection of Cervical Precancer in HPV-Positive Women. J Natl Cancer Inst. 2015;107 (12):djv257. - PMC - PubMed

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