Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Nov 13;2(4):ofv176.
doi: 10.1093/ofid/ofv176. eCollection 2015 Dec.

An Evaluation of Systemic Vancomycin Dosing in Obese Patients

David W Kubiak  1 , Mohammed Alquwaizani  1 , David Sansonetti  1 , Megan E Barra  1 , Michael S Calderwood  1
Affiliations

An Evaluation of Systemic Vancomycin Dosing in Obese Patients

David W Kubiak et al. Open Forum Infect Dis. .

Abstract

We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.

Keywords: obese; pharmacokinetics; vancomycin.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009–2010. NCHS Data Brief 2012; 1–8. - PubMed
    1. World Health Organization. Obesity and overweight. Fact sheet 311. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/ Accessed 4 May 2015.
    1. Rybak M, Lomaestro B, Rotschafer JC et al. . Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm 2009; 66:82–98. - PubMed
    1. Adane ED, Herald M, Koura F. Pharmacokinetics of vancomycin in extremely obese patients with suspected or confirmed Staphylococcus aureus infections. Pharmacotherapy 2015; 35:127–39. - PubMed
    1. Bauer LA, Black DJ, Lill JS. Vancomycin dosing in morbidly obese patients. Eur J Clin Pharmacol 1998; 54:621–5. - PubMed

LinkOut - more resources