[Does the renal threshold change? Insulin therapy, based on urine glucose concentration, controlled by a dosage-measuring computer]

Abstract

The insulin treatment of 8 diabetic patients was controlled by a microprocessor in order to compare dosage adjustment based on blood glucose and urine glucose determination. In the first month of the treatment the modifications in the insulin doses were suggested by the devices accordingly to blood glucose values, determined by the patients at home four times daily. Then the treatment was guided by the first voided urine glucose concentrations for three months. The treatment based on urine glucose concentration insured the good metabolic control previously achieved by blood glucose values on the basis of blood glucose profile and glycohaemoglobin values. There was no difference between the two treatments in the occurrence of hypoglycemia. The average of the patients renal threshold measured by the authors' method came close to the normal value and proved to be almost constantly related to every single patient. The results support glucosuria-based dosage adjustment as a supplementary for glucose control.