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Comment
. 2016 Jan 12;113(2):246-7.
doi: 10.1073/pnas.1523319113. Epub 2015 Dec 30.

Sour taste finds closure in a potassium channel

Rosemary C Challis  1 , Minghong Ma  2
Affiliations
Comment

Sour taste finds closure in a potassium channel

Rosemary C Challis et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Potential contribution of the KIR2.1 channel in sour and nonsour taste cells. (A) In sour (PKD2L1) taste cells, weak acid causes stronger AP firing (Upper) than strong acid (Lower) at the same pH, presumably by intracellular acidification. (B, Upper) In nonsour (TRPM5) taste cells, weak acid stimulation does not cause AP firing, likely due to the large KIR2.1 current. (B, Lower) When the KIR2.1 current is mostly blocked, weak acid stimulation can cause AP firing.
See this image and copyright information in PMC

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