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. 2015 Dec 31;6(12):e2038.
doi: 10.1038/cddis.2015.385.

Necrotic cone photoreceptor cell death in retinitis pigmentosa

Y Murakami  1 , Y Ikeda  1 , S Nakatake  1 , J W Miller  2 , D G Vavvas  2 , K H Sonoda  1 , T Ishibashi  1
Affiliations

Necrotic cone photoreceptor cell death in retinitis pigmentosa

Y Murakami et al. Cell Death Dis. .
No abstract available

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Figures

Figure 1
Figure 1
Rod and cone photoreceptor cell death in retinitis pigmentosa. Rod cell death due to the deleterious genetic mutations is associated with apoptosis, which involves the activation of caspase-independent pathways including poly-ADP-ribose-polymerase (PARP), calpain and histone deacetylase (HDAC). Cone cell death is induced by the microenviromental changes subsequent to rod degeneration, such as oxidation, inflammation and loss of trophic factors. Dying cones show different morphological features from rod cells, such as necrotic cytoplasmic swelling (asterisk), and is partly mediated through the activation of RIP kinase (RIPK). Electron microscopy images were reproduced with permissions from Murakami et al.5 mToR, mammalian target of rapamycin; RdCVF, rod-derived cone viability factor; TNF-α, tumor necrosis factor-α
See this image and copyright information in PMC

References

    1. 1Vandenabeele P et al. Nat Rev Mol Cell Biol 2010; 11: 700–714. - PubMed
    1. 2Chang GQ et al. Neuron 1993; 11: 595–605. - PubMed
    1. 3Sahaboglu A et al. Cell Death Dis 2013; 4: e488. - PMC - PubMed
    1. 4Arango-Gonzalez B et al. PLoS One 2014; 9: e112142. - PMC - PubMed
    1. 5Murakami Y et al. Proc Natl Acad Sci USA 2012; 109: 14598–14603. - PMC - PubMed

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