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Comment
. 2015 Dec 31;11(12):e1005743.
doi: 10.1371/journal.pgen.1005743. eCollection 2015 Dec.

Why Are tRNAs Overproduced in the Absence of Maf1, a Negative Regulator of RNAP III, Not Fully Functional?

Magdalena Boguta  1
Affiliations
Comment

Why Are tRNAs Overproduced in the Absence of Maf1, a Negative Regulator of RNAP III, Not Fully Functional?

Magdalena Boguta. PLoS Genet. .
No abstract available

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Conflict of interest statement

The author has declared that no competing interests exist.

Figures

Fig 1
Fig 1. A novel link between RNAP III transcription and tRNA modification.
Transcription of tRNA precursors by RNA polymerase III (RNAP III) in the nucleus is controlled by the general repressor Maf1. Initial 5' and 3' end maturation including addition of CCA sequence, takes place in the nucleus. Following m2 2G26 modification by Trm1 methyltransferase tethered to the inner nuclear membrane, tRNAs are exported to the cytoplasm, charged, and directed to translation machinery. A previously unknown link connecting RNAP III activity and m2 2G26 efficiency, due to a limiting amount of Trm1, is designated by a dashed line. Splicing of intron-containing tRNA precursors and other modifications that can be added in each step of tRNA biosynthesis are not presented on the scheme.
See this image and copyright information in PMC

Comment on

References

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