Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth

Abstract

Cervical adenosarcomas are exceedingly infrequent tumors that occur most often in women of reproductive age. Adenosarcomas comprise benign epithelial elements and malignant stromal elements. The malignant stromal elements can either be homologous, such as fibroblasts or smooth muscle, or heterologous, like cartilage, striated muscle, or bone. We report a case of adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth in a 38-year-old woman.

Figure 1.

(a) Stromal condensation underneath the endocervical surface epithelium (hematoxylin and eosin [H&E] 100×). (b) Small round blue cells within the endocervical stroma (H&E 400x). (c) Small round blue cells surrounding vessels (H&E 400×). (d) Foci of skeletal muscle consistent with rhabdomyoblasts (H&E 100×).

Figure 2.

(a) Periglandular cuffing of stromal cells (hematoxylin and eosin [H&E], 200×). (b) Stromal overgrowth underneath the surface epithelium (H&E 200×). (c) Foci of benign cartilage (H&E 200×). (d) Foci of rhabdomyoblasts present within the main resection specimen (H&E 400×).