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. 2015 Dec 31:19:14.
doi: 10.1186/s40824-015-0036-0. eCollection 2015.

Long and short range order structural analysis of In-situ formed biphasic calcium phosphates

Dong-Hyun Kim  1 , Kyu-Hong Hwang  2 , Ju Dong Lee  3 , Hong-Chae Park  1 , Seog-Young Yoon  1
Affiliations

Long and short range order structural analysis of In-situ formed biphasic calcium phosphates

Dong-Hyun Kim et al. Biomater Res. .

Abstract

Background: Biphasic calcium phosphates (BCP) have attracted considerable attention as a bone graft substitute. In this study, BCP were prepared by aqueous co-precipitation and calcination method. The crystal phases of in-situ formed BCP consisting of hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) were controlled by the degree of calcium deficiency of precursors. The long and short range order structures of biphasic mixtures was investigated using Rietveld refinement technique and high resolution Raman spectroscopy. The refined structural parameters of in-situ formed BCP confirmed that all the investigated structures have crystallized in the corresponding hexagonal (space group P63/m) and rhombohedral (space group R3c) structures.

Results: The crystal phases, Ca/P molar ratio, and lattice parameters of in-situ formed BCP consisting of HAp and β-TCP were controlled by the degree of calcium deficiency of calcium phosphate precursors. The significant short range order structural change of BCP was determined by Raman analysis.

Conclusions: The long and short range order structural changes of in-situ formed BCP might be due to the coexistence of β-TCP and HAp crystal phases.

Keywords: Biphasic calcium phosphate; Raman spectroscopy; Rietveld refinement.

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Figures

Fig. 1
Fig. 1
a Rietveld analysis patterns of powder diffraction data of BCP and b molar Ca/P ratio of BCP calculated using Rietveld method
Fig. 2
Fig. 2
a XRD patterns, b axial ratio, and c volumetric expansion behavior of unit cells of in-situ formed BCP. (Note: axis of β-TCP and HAp is a = b and axial angle is α = β = 90°, γ = 120°)
Fig. 3
Fig. 3
a Symmetric vibration (stretching mode, ν1) of PO3 4− of β-TCP, HAp, mechanical mixed BCP, and in-situ formed BCP and b pseudo Gaussian fitting results from Raman spectra of in-situ formed BCP
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References

    1. De Groot K. Clinical applications of calcium phosphate biomaterials: a review. Ceram Int. 1993;19:363–366. doi: 10.1016/0272-8842(93)90050-2. - DOI
    1. Jarcho M. Biomaterial aspects of calcium phosphates. Dent Clin North Am. 1986;30:25–47. - PubMed
    1. Bucholz RW, Carlton A, Holmes RE. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop Clin North Am. 1987;18:323–334. - PubMed
    1. Hench LL, Am J. Bioceramics. Ceram Soc. 1998;81:1705–1728. doi: 10.1111/j.1151-2916.1998.tb02540.x. - DOI
    1. Klein CPAT, Driessen AA, De Groot K, van den Hooff A, Biomed J. Biodegradation behaviour of various calcium phosphate materials in bone tissue. Mater Res A. 1983;17:769–784. - PubMed

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