Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: case report

Abstract

Phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) are tumors that may cause tumor-induced osteomalacia and rarely appear intracranially. The authors describe the case of an 8-year-old girl who was found to have PMT-MCT with involvement of the cerebellar hemisphere and a small tumor pedicle breaching the dura mater and involving the skull. This was removed surgically in gross-total fashion without further complication. Histologically the tumor was confirmed to be a PMT-MCT. There was no evidence of tumor-induced osteomalacia. At the 42-month follow-up, the patient is doing well, has no abnormalities, and is free of recurrence. PMT-MCTs are rare tumors that may involve the brain parenchyma. A gross-total resection may be effective to cure these lesions.

Keywords: ABC = aneurysmal bone cyst; PMT-MCT = phosphaturic mesenchymal tumor (mixed connective tissue variant); RT-PCR = reverse transcriptase polymerase chain reaction; TIO = tumor-induced osteomalacia; cerebellar tumor; fibroblast growth factor 23; oncology; pediatric brain tumor; phosphaturic mesenchymal tumor.