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Review
. 1989 Jul;10(7):281-5.
doi: 10.1016/0165-6147(89)90029-1.

Role of Ca2+ in toxic cell killing

S Orrenius, D J McConkey, G Bellomo, P Nicotera
Review

Role of Ca2+ in toxic cell killing

S Orrenius et al. Trends Pharmacol Sci. 1989 Jul.

Abstract

Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.

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