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Case Reports
. 1977 May;53(619):267-9.
doi: 10.1136/pgmj.53.619.267.

Portal hypertension in a patient with chronic myeloid leukaemia

M D Foadi, S Shaw, F J Paradinas
Case Reports

Portal hypertension in a patient with chronic myeloid leukaemia

M D Foadi et al. Postgrad Med J. 1977 May.

Abstract

A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice. At post-mortem there was minimal leukaemic infiltration but there were alterations in the liver architecture sufficient to explain the portal hypertension. The pathogenesis of the liver changes and their possible relationship to splenomegaly and busulphan toxicity are considered.

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References

    1. Br J Haematol. 1975 Nov;31(3):279-85 - PubMed
    1. Clin Sci. 1970 Jan;38(1):73-84 - PubMed
    1. Br Med J. 1970 Jan 17;1(5689):131-5 - PubMed

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