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. 2016 Jan 5:16:3.
doi: 10.1186/s12872-015-0178-y.

Rapid predictors for the occurrence of reduced left ventricular ejection fraction between LAD and non-LAD related ST-elevation myocardial infarction

Zhang-Wei Chen  1 , Zi-Qing Yu  1 , Hong-Bo Yang  1 , Ying-Hua Chen  2 , Ju-Ying Qian  3 , Xian-Hong Shu  1 , Jun-Bo Ge  4
Affiliations

Rapid predictors for the occurrence of reduced left ventricular ejection fraction between LAD and non-LAD related ST-elevation myocardial infarction

Zhang-Wei Chen et al. BMC Cardiovasc Disord. .

Abstract

Backgrounds: Reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), which implies the occurrence of cardiac dysfunction, impacts cardiac prognosis, even after primary percutaneous coronary intervention (PCI). This study was designed to clarify the difference of clinical and angiographic predictors for reduced LVEF in ST-elevation myocardial infarction (STEMI) patients with left anterior descending artery (LAD) or non-LAD vessel as culprit artery.

Methods: This was a retrospective study to review a total of 553 patients of STEMI underwent primary PCI in our hospital. All patients underwent echocardiography. Univariate analysis, multivariate analysis and classification and regression tree (CART) were performed between LAD related AMI and non-LAD related STEMI. The primary outcome was the occurrence of reduced LVEF 4-6 days after PCI.

Results: In this study, culprit arteries of STEMI were 315 in LAD system (6 in left main artery, 309 in LAD) and 238 in non-LAD system (63 in left circumflex and 175 in right coronary artery). Compared with non-LAD group, post-MI LVEF was significantly reduced in LAD related STEMI group (52.4 ± 9.3% vs. 57.1 ± 7.8%, P < 0.01). Multivariate analysis indicated that elder (>65 years), time to hospital and proximal occlusion were associated with reduced LVEF (<55%) in LAD related STEMI patients. However, in non-LAD patients, time to hospital, multivessel stenosis and post-PCI blood pressure predicted the occurrence of reduced LVEF. Furthermore, CART analysis also obtained similar findings.

Conclusions: Patients with LAD or non-LAD related STEMI could suffer reduced LVEF, while the clinical and angiographic predictors for the occurrence were different.

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Figures

Fig. 1
Fig. 1
Subgroups analysis of clinical and angiographic factors for the increasing risk of reduced LVEF (LVEF < 55 %) in LAD and non-LAD related STEMI groups
Fig. 2
Fig. 2
LAD system: STEMI in left main or left main artery or left anterior descending artery; Non-LAD system: STEMI in left circumflex or right coronary artery; DBP: diastolic blood pressure; SBP: systolic blood pressure; Groups A to D indicated four groups classified by the quartile of post-PCI blood pressure SBP: group A: <102mmHg; Group B: 103-110mmHg; Group C: 111-120mmHg; Group D: >120mmHg DBP: group A: <65mmHg; Group B: 66-70mmHg; Group C: 71-78mmHg; Group D: >79mmHg. The incidence of reduced LVEF in different post-PCI blood pressure subgroups
Fig. 3
Fig. 3
CART analysis demonstrated the major predictors and diagnostic steps for reduced LVEF
See this image and copyright information in PMC

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