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Review
. 2015 Dec 30;17(1):48.
doi: 10.3390/ijms17010048.

Notch Signaling in Pancreatic Development

Xu-Yan Li  1   2 , Wen-Jun Zhai  3 , Chun-Bo Teng  4
Affiliations
Review

Notch Signaling in Pancreatic Development

Xu-Yan Li et al. Int J Mol Sci. .

Abstract

The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.

Keywords: Notch signaling; differentiation; maintenance; pancreatic progenitor.

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Figures

Figure 1
Figure 1
A schematic of pancreatic development.
Figure 2
Figure 2
A schematic of Notch signaling during pancreatic development. Notch signaling is initiated by the binding of the ligands and receptors of two neighboring cells. Upon activation, Notch is cleaved, releasing the Notch intracellular domain (NICD). The NICD can subsequently translocate into the nucleus to transcriptionally activate Notch target genes. Hes1 inhibits the expression of Ngn3 by blocking its promoter activity.
Figure 3
Figure 3
Notch-mediated lateral inhibition in pancreatic multipotent progenitor cell differentiation.
Figure 4
Figure 4
Notch signaling in the proliferation of pancreatic multipotent progenitor cells.
Figure 5
Figure 5
Inhibitory crosstalk between the Wingless and INT-1 (Wnt) and Notch pathways in pancreatic progenitor cells. The dashed lines signify that the mechanisms existing in the pancreas are unknown. The arrows represent activation whereas bar-headed lines represent inhibition.
Figure 6
Figure 6
The crosstalk between the fibroblast growth factor (FGF) and Notch pathways in pancreatic progenitors. The dashed lines signify that the mechanisms existing in the pancreas are unknown. The arrows represent activation whereas bar-headed lines represent inhibition.
See this image and copyright information in PMC

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