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. 1989 Jul;50(7):1138-40.

Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves

V L Douglas  1 , J S Cullor, J W Tyler, M C Thurmond, R B Bushnell
Affiliations
  • PMID: 2672915

Rapid decay of serum IgG recognizing gram-negative cell wall core antigens in neonatal calves

V L Douglas et al. Am J Vet Res. 1989 Jul.

Abstract

Serum immunoglobulins of the IgG isotype recognizing common gram-negative cell core epitopes were serially measured, using a direct ELISA, on samples obtained from 20 neonatal Holstein calves. An R-mutant Escherichia coli (strain J5) was used as a plate antigen in this assay. Total serum IgG concentration was measured using radial immunodiffusion. Half-lives of core antigen-specific IgG (7.56 days) and total serum IgG (22.66 days) were dramatically different (P less than 0.0005). This may be an indication of cross-reactive consumption of core antigen-specific immunoglobulins.

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