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. 2016 May;30(5):239-42.
doi: 10.1002/jbt.21784. Epub 2016 Jan 5.

The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

Lilian I L Wong  1 , Alexandra R Reers  1 , Heidi A Currier  1 , Tony D Williams  1 , Michael E Cox  2 , John E Elliott  3 , Timothy V Beischlag  4
Affiliations

The Effects of the Organic Flame-Retardant 1,2-Dibromo-4-(1,2-dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines

Lilian I L Wong et al. J Biochem Mol Toxicol. 2016 May.

Abstract

The effects of the organic flame retardant 1,2-Dibromo-4-(1,2-dibromoethyl) cyclohexane (TBECH) on androgen receptor target gene expression were examined in the human LNCaP prostate cancer cell line. While γ-/δ-TBECH alone led to a significant increase in prostate-specific antigen (PSA) mRNA accumulation, both the α-/-TBECH and γ-/δ-TBECH mixtures repressed androgen-inducible PSA mRNA and protein accumulation in human LNCaP cells. Thus, we hypothesize that isomeric mixtures of TBECH may act as partial agonists of the androgen receptor.

Keywords: Androgen Receptor; Endocrine Disruptor; LNCaP; Organic Flame Retardant.

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