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. 2016 Jan 4;6(1):e008973.
doi: 10.1136/bmjopen-2015-008973.

Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials

Wenming Zhang  1 , Shangquan Wang  2 , Ranxing Zhang  3 , Yuanyuan Zhang  1 , Xinjian Li  1 , Yanping Lin  1 , Xu Wei  4
Affiliations

Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials

Wenming Zhang et al. BMJ Open. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] BMJ Open. 2016 Jan 19;6(1):e008973corr1. doi: 10.1136/bmjopen-2015-008973corr1. BMJ Open. 2016. PMID: 26787247 Free PMC article. No abstract available.

Abstract

Objectives: Duhuo Jisheng decoction (DJD) is considered beneficial for controlling knee osteoarthritis (KOA)-related symptoms in some Asian countries. This review compiles the evidence from randomised clinical trials and quantifies the effects of DJD on KOA.

Designs: 7 online databases were investigated up to 12 October 2015. Randomised clinical trials investigating treatment of KOA for which DJD was used either as a monotherapy or in combination with conventional therapy compared to no intervention, placebo or conventional therapy, were included. The outcomes included the evaluation of functional activities, pain and adverse effect. The risk of bias was evaluated using the Cochrane Collaboration tool. The estimated mean difference (MD) and SMD was within a 95% CI with respect to interstudy heterogeneity.

Results: 12 studies with 982 participants were identified. The quality presented a high risk of bias. Meta-analysis found that DJD combined with glucosamine (MD 4.20 (1.72 to 6.69); p<0.001) or DJD plus meloxicam and glucosamine (MD 3.48 (1.59 to 5.37); p<0.001) had a more significant effect in improving Western Ontario and McMaster Universities Arthritis Index (total WOMAC scores). Also, meta-analysis presented more remarkable pain improvement when DJD plus sodium hyaluronate injection (MD 0.89 (0.26 to 1.53); p=0.006) was used. These studies demonstrated that active treatment of DJD in combination should be practiced for at least 4 weeks. Information on the safety of DJD or comprehensive therapies was insufficient in few studies.

Conclusions: DJD combined with Western medicine or sodium hyaluronate injection appears to have benefits for KOA. However, the effectiveness and safety of DJD is uncertain because of the limited number of trials and low methodological quality. Therefore, practitioners should be cautious when applying DJD in daily practice. Future clinical trials should be well designed; more research is needed.

Keywords: COMPLEMENTARY MEDICINE; Duohuo jisheng decoction; knee osteoarthritis.

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Figures

Figure 1
Figure 1
PRISMA 2009 flow diagram (RCT, randomised controlled trial).
Figure 2
Figure 2
Forest plot of the effect of Duhuo Jisheng decoction plus glucosamine versus glucosamine in total WOMAC scores.
Figure 3
Figure 3
Forest plot of the effect of Duhuo Jisheng decoction plus meloxicam and glucosamine, versus meloxicam and glucosamine, in total WOMAC scores.
Figure 4
Figure 4
Forest plot of the effect of Duhuo Jisheng decoction plus sodium hyaluronate injection versus sodium hyaluronate injection in visual analogue scale (VAS) scores.
See this image and copyright information in PMC

References

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