Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec;29(4):583-594.
doi: 10.1177/0394632015623793. Epub 2016 Jan 4.

Inflammatory markers and suicidal attempts in depressed patients: A review

Stefano Marini  1 , Federica Vellante  2 , Ilaria Matarazzo  2 , Domenico De Berardis  2   3 , Nicola Serroni  3 , Daniela Gianfelice  3 , Luigi Olivieri  3 , Fulvia Di Renzo  3 , Anna Di Marco  3 , Michele Fornaro  4 , Laura Orsolini  5   6 , Alessandro Valchera  7 , Felice Iasevoli  8 , Monica Mazza  9 , Giampaolo Perna  10   11   12 , Giovanni Martinotti  2 , Massimo Di Giannantonio  2
Affiliations
Review

Inflammatory markers and suicidal attempts in depressed patients: A review

Stefano Marini et al. Int J Immunopathol Pharmacol. 2016 Dec.

Abstract

Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.

Keywords: inflammatory markers; major depressive disorder; suicidal attempts.

PubMed Disclaimer

Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Publishing.
    1. Réka S, Zoltán J, Kálmán J. (2012) The blue side of glutamatergic neurotransmission: NMDA receptor antagonists as possible novel therapeutics for major depression. Neuropsychopharmacologia Hungarica 14: 29–40. - PubMed
    1. Greer TL, Kurian BT, Trivedi MH. (2010) Defining and measuring functional recovery from depression. CNS Drugs 24: 267–284. - PubMed
    1. Pompili M, Serafini G, Innamorati M, et al. (2011) Suicide risk in first episode psychosis: A selective review of the current literature. Schizophrenia Research 129: 1–11. - PubMed
    1. Pompili M, Innamorati M, Rihmer Z, et al. Cyclothymic-depressive anxious temperament pattern is related to suicide risk in 346 patients with major mood disorders. Journal of Affective Disorders 136: 405–411. - PubMed

LinkOut - more resources