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Review
. 2015 Nov 23;7(4):5844.
doi: 10.4081/hr.2015.5844.

The Anti-Factor Xa Range For Low Molecular Weight Heparin Thromboprophylaxis

Matthew Y Wei  1 , Salena M Ward  1
Affiliations
Review

The Anti-Factor Xa Range For Low Molecular Weight Heparin Thromboprophylaxis

Matthew Y Wei et al. Hematol Rep. .

Abstract

Low molecular weight heparins (LMWHs) are now the mainstay option in the prevention and treatment of venous thromboembolism. In some patients receiving therapeutic doses of LMWH, activity can be measured by quantifying the presence of Anti-factor Xa (AFXa) for dose adjustment. However, currently there are no guidelines for LMWH monitoring in patients on thromboprophylactic, doses, despite certain patient populations may be at risk of suboptimal dosing. This review found that while the AFXa ranges for therapeutic levels of LMWHs are relatively well defined in the literature, prophylactic ranges are much less clear, thus making it difficult to interpret current research data. From the studies published to date, we concluded that a reasonable AFXa target range for LMWH deep venous thromboses prophylaxis might be 0.2-0.5 IU/mL.

Keywords: Low molecular weight heparin; anti-factor Xa; venous thromboembolism.

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Conflict of interest statement

Conflict of interest: the authors declare no potential conflict of interest.

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