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. 2015 Nov 6;17(11):e17278.
doi: 10.5812/ircmj.17278. eCollection 2015 Nov.

Immunohistochemical Assessment of HER3 Expression in Odontogenic Cysts

Marieh Honarmand  1 , Shirin Saravani  2 , Nazanin Kamyab  3 , Mehdi Jahantigh  4 , Molouk Torabi Parizi  5
Affiliations

Immunohistochemical Assessment of HER3 Expression in Odontogenic Cysts

Marieh Honarmand et al. Iran Red Crescent Med J. .

Abstract

Background: It has been demonstrated that HER3 plays an important role in some human cancers and the HER3 expression is associated with worse survival in solid tumors.

Objectives: This study was conducted to compare HER3 expression in epithelial lining of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs).

Materials and methods: This was a descriptive-analytical study, which assessed all 57 paraffin blocks of RCs, DCs and OKCs (21 RCs, 16 DCs, 20 OKC) from pathological archive of Dentistry College of Zahedan, Iran. The HER3 expression in cytoplasm and membrane was examined by immunohistochemical method. The data collected was analyzed using SPSS16 by ANOVA and Chi-square. P < 0.05 was considered as statistically significant.

Results: The HER3 expression had positive results in 52.4% of OKC, 50% of DC and only 20% of RC samples. There was a significant difference between HER3 expression in OKCs and RCs.

Conclusions: The HER3 expression in developmental odontogenic cysts was higher than that in inflammatory odontogenic cysts. The higher rate of HER3 expression in OKC may justify inherent growth potential, stimulation-independent proliferation capability, invasive growth and high recurrence rate of the cyst accepted today as a tumor.

Keywords: Dentigerous Cyst; Human Epidermal Growth Factor Receptor3; Odontogenic Cysts; Radicular Cyst.

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Figures

Figure 1.
Figure 1.. Immunohistochemical Staining With HER3 in Odontogenic Cyst
A, Staining pattern with high intensity of epithelial covered cells of OKC. B, Staining pattern with moderate intensity of epithelial covered cells of OKC in basal and supra-basal layers. C, Staining pattern with week intensity of epithelial covered cells of dentigerous cyst. D, Non-stained epithelial cover cells of radicular cyst (Magnification × 400).
See this image and copyright information in PMC

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