Salivary Antimicrobial Peptides in Early Detection of Periodontitis

Abstract

In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supporting tissues, there is a complex interaction between the subgingival microbiota and host tissues. A periodontal diagnostic tool for detecting the initiation and progression of the disease, monitoring the response to therapy, or measuring the degree of susceptibility to future disease progression has been of interest for a long time. The value of various enzymes, proteins, and immunoglobulins, which are abundant constituents of saliva, as potential biomarkers has been recognized and extensively investigated for periodontal diseases. Gingival defensins and cathelicidins are small cationic antimicrobial peptides that play an important role in innate immune response. However, their applicability as salivary biomarkers is still under debate. The present review focuses on proteomic biomarkers and antimicrobial peptides, in particular, to be used at early phases of periodontitis.

Keywords: antimicrobial peptides; biomarker; periodontitis; saliva.

Figure 1

Limitations in the use of antimicrobial defensins as salivary biomarkers of periodontitis (T, Tooth; C, Connective Tissue; A, Alveolar Bone; E, Epithelium; red dots, α-defensins; blue dots, β-defensins).