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. 1989 Jul;4(4):425-9.

Treatment of advanced Hodgkin's disease with high dose melphalan and autologous bone marrow transplantation

J A Russell  1 , P J Selby, B A Ruether, E K Mbidde, S Ashley, G Zulian, J Berry, B Houwen, A R Jones, M C Poon, et al.
Affiliations
  • PMID: 2673463

Treatment of advanced Hodgkin's disease with high dose melphalan and autologous bone marrow transplantation

J A Russell et al. Bone Marrow Transplant. 1989 Jul.

Abstract

Twenty patients with Hodgkin's disease which had relapsed at least once after chemotherapy, were treated with melphalan 140-220 mg/m2 i.v. followed by reinfusion of non-cryopreserved autologous bone marrow. Four patients (20%) remain alive and disease-free 28, 45, 52, and 96 months after treatment respectively. There were no treatment-related deaths. This appears to be the only reported series of patients treated with a single agent in this situation. The results are comparable to those achieved by multi-agent regimens with autologous or allogeneic bone marrow transplantation.

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