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. 2015 Dec;3(21):343.
doi: 10.3978/j.issn.2305-5839.2015.11.36.

Interfering with the IFN-γ/CXCL10 pathway to develop new targeted treatments for vitiligo

Mehdi Rashighi  1 , John E Harris  1
Affiliations

Interfering with the IFN-γ/CXCL10 pathway to develop new targeted treatments for vitiligo

Mehdi Rashighi et al. Ann Transl Med. 2015 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
IFN-γ/CXCL10 signaling pathway in vitiligo. Binding of IFN-γ to its receptor (IFN-γR) activates the JAK-STAT pathway and leads to CXCL10 secretion in the skin. CXCL10 promotes recruitment of additional autoreactive CD8+ T cells through its cognate receptor (CXCR3), which increases inflammation through a positive feedback loop. Compounds that have been developed to target each step are indicated in red.
See this image and copyright information in PMC

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