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Case Reports
. 2015 Nov-Dec;90(6):909-11.
doi: 10.1590/abd1806-4841.20153818.

Syndrome in question

Priscila Regina Orso Rebellato  1 , Camila Makino Rezende  1 , Eveline Roesler Battaglin  1 , Brunno Zeni de Lima  1 , Jose Fillus Neto  1
Affiliations
Case Reports

Syndrome in question

Priscila Regina Orso Rebellato et al. An Bras Dermatol. 2015 Nov-Dec.

Abstract

Morbihan Syndrome is a rare entity with unknown etiology. It is clinically characterized by chronic erythematous edema on the face - especially in the middle and upper third of the face - and creates abnormal facial contours that are initially intermitent but become permanent with the development of the syndrome. The histopathology is nonspecific and its therapy is a major challenge due to poor response to the various treatment options. We present the case of a male patient with a five-month-history of disease.

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Conflict of interest statement

Conflict of Interest: None

Figures

Figure 1
Figure 1
Periorbital edema, larger on the upper eyelid, with superimposed erythematous papules (Figure 1).
Figure 2
Figure 2
Intact basal layer. Superficial dermis with vessel ectasia, mild fibrosis, edema and mild inflammatory infiltrate of mononuclear cells (400x HE)
Figure 3
Figure 3
Evident increase in the number of mast cells and increased vascular dilatation (100x Giemsa stain)
See this image and copyright information in PMC

References

    1. Smith AL, Cohen DE. Successful long-term use of oral isotretinoin for the management of Morbihan Disease. Arch Dermatol. 2012;148:1395–1398. - PubMed
    1. Romiti N. Morbus Morbihan: solid and persistent facial edema and erythema. An Bras Dermatol. 2000;75:599–603.
    1. Franco M, Parra IH, Bibiloni N, Kowalczuk A, Galimberti R. Enfermidad de Morbihan. Dermatol Argent. 2009;15:434–436.
    1. Estudillo ZFB, Gómez MIR, Ibarra MML, Ramírez MJQ. Edema sólido facial persistente relacionado com acne (Morbihan) Dermatol Rev Mex. 2012;56:341–345.
    1. Veraldi S, Persico MC, Francia C. Morbihan Syndrome. Indian Dermatol Online J. 2013;4:122–124. - PMC - PubMed

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