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. 2015 Aug:2015:1361-4.
doi: 10.1109/EMBC.2015.7318621.

A smart pill for drug delivery with sensing capabilities

R Goffredo, D Accoto, M Santonico, G Pennazza, E Guglielmelli

A smart pill for drug delivery with sensing capabilities

R Goffredo et al. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug.

Abstract

In this paper a novel system for local drug delivery is described. The actuation principle of the micropump used for drug delivery relies on the electrolysis of a water-based solution, which is separated from a drug reservoir by an elastic membrane. The electrolytically produced gases pressurize the electrolytic solution reservoir, causing the deflection of the elastic membrane. Such deflection, in turn, forces the drug out of its reservoir through a nozzle. The proposed system is integrated in a swallowable capsule, equipped with an impedance sensor useful to acquire information on the physiological conditions of the tissue. Such information can be used to control pump activation.

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