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. 2015 Aug:2015:4439-42.
doi: 10.1109/EMBC.2015.7319380.

Procoagulant control strategies for the human blood clotting process

Marco Laurino, Tommaso Menara, Alessandro Stella, Monica Betta, Alberto Landi

Procoagulant control strategies for the human blood clotting process

Marco Laurino et al. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug.

Abstract

This paper describes the comparison between two drug control strategies to hemophilia A. To emulate blood clotting and the pathological condition of hemophilia, a mathematical model composed by 14 ordinary differential equations is considered. We adopt a variable structure non-linear PID approach and a Model Predictive Control in order to control the dosage of procoagulant factor used in the treatment of hemophiliac patient. The two control actions are sampled for a practical application. Finally, we discuss and compare the results of the two control approaches, introducing a suited control index (eINR).

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