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Review
. 2016 Mar;25(3):167-73.
doi: 10.1111/exd.12929. Epub 2016 Feb 10.

Antimicrobial peptides and wound healing: biological and therapeutic considerations

Maria Luisa Mangoni  1 , Alison M McDermott  2 , Michael Zasloff  3
Affiliations
Review

Antimicrobial peptides and wound healing: biological and therapeutic considerations

Maria Luisa Mangoni et al. Exp Dermatol. 2016 Mar.

Abstract

Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

Keywords: antibiotic resistance; antimicrobial peptide; frog skin; innate immunity; skin infections; wound healing.

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Conflict of interest statement

Conflict of interests

The authors declare no conflict of interest

Figures

Figure 1
Figure 1
Schematic representation of biological functions of AMPs, beneficial for wound healing
See this image and copyright information in PMC

Comment in

  • AMP-lification of wound healing.
    Bíró T, Harder J. Bíró T, et al. Exp Dermatol. 2016 Aug;25(8):592-3. doi: 10.1111/exd.13039. Exp Dermatol. 2016. PMID: 27094016 No abstract available.

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